About anti-obesity effect of Extract A and Extract B mixed in VIVOU gel

Our company got a question about anti-obesity effect related to VIVOU gel (Extract A and Extract B). Firstly, we would like to notify you that it took time to find the university science laboratory where is able to make an experiment, and it also took time to get the significant experiment result.

These experiment were done 2 times at the biofunction development laboratory of the university.

​

(1) 1st Experiment Report (April 7, 2017)

We tried to make and experiment about anti-obesity effect of Extract A and Extract B, but did not find significant effect to lipolysis in test sample. And we considered the effectiveness to fat cumulative action by using precursory fat cell, but we also did not find significant effect to lipolysis in test sample.

​

<Problem in 1st experiment>

In this lipolysis test, because of using matured fat-cell until fat droplet get bigger, it is possible that the difference of effectiveness by sample was difficult to find. Therefore, it is required to continuously consider the effect against lipolysis by making fat-cell in different maturity stage in next step.

​

(2) 2nd Experiment Report (August 10, 2017)

Base on 1st experiment result, in 2nd experiment, we changed the condition about effect against lipolysis in fat-cell to evaluate the effect against fat metabolism about Extract A and Extract B. As the result, even in this experiment condition, the significant effect to lipolysis is not found in test sample. But, for lipase activity which is lipolytic enzyme we got the result in 2nd experiment, as the result of checking in cell level and test tube level, we found strong lipase activity in Extract B which is lots of benefit for us. However, we did not find the effect in Extract A.

​

Moreover, we got the result as followings about the effect against inflammatory response which is related to the formation of fatness pathology. To sum up, as the evaluation result for the production of nitrogen monoxide (NO) which is a type of active oxygen by using macrophage cell line RAW264.7, we found inhibitory effect to the production of nitrogen monoxide (NO) in Extract A., and it is hinted for inflammatory response. We can sententiously summarize the above as below.

​

     (1) We found strong lipase activity in Extract B.

     (2) Extract A is related to the formation of fatness pathology.

​

It is hinted for inflammatory response. There is document 1.2 in report of inflammatory response of Extract A.

​

[Prospect and Problem]

This time result is limited to experiment condition, but there are multiple similar reports, so it gave the hint that it is useful even in daily life.

​

In the future, we suppose that we can see many developments of cosmetic product which can be expected for the effectiveness close to drug medicine such as anti-inflammatory action which is related to learn figure or formation of fatness pathology by lipolysis.